# Studies on the shelf

> A reading shelf for Sedona Telehealth — Sedona Telehealth’s reading list: Selank studies on rat gene expression, hippocampal BDNF, plasma enzymes, anxiety and immune signals.

The opening rat experiment comes first; the other papers lead toward different questions.

## The frontal-cortex starting point

[Selank administration and GABA-related gene expression](https://pubmed.ncbi.nlm.nih.gov/26924987/) is the starting point for the busy-quiet idea. The [hippocampal BDNF study](https://pubmed.ncbi.nlm.nih.gov/18841804/) supplies a separate rat experiment, located elsewhere in the brain.

## Plasma and patient studies

The [human-plasma enzyme paper](https://pubmed.ncbi.nlm.nih.gov/11550013/) proposes an anxiety-related mechanism. The [generalized-anxiety clinical report](https://pubmed.ncbi.nlm.nih.gov/18454096/) concerns effects in patients. The [immune study in anxiety-asthenic disorders](https://pubmed.ncbi.nlm.nih.gov/18577961/) brings cytokine balance and IL-6 expression into the discussion. I approach this small shelf with a different question for each paper.

## References

[1] Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission https://pubmed.ncbi.nlm.nih.gov/26924987/
[2] Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo https://pubmed.ncbi.nlm.nih.gov/18841804/
[3] The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity https://pubmed.ncbi.nlm.nih.gov/11550013/
[4] Efficacy and possible mechanisms of action of a new peptide anxiolytic medication (selank) in the therapy of generalized anxiety disorders and neurasthenia https://pubmed.ncbi.nlm.nih.gov/18454096/
[5] Immunomodulatory effects of selank in patients with anxiety-asthenic disorders https://pubmed.ncbi.nlm.nih.gov/18577961/

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At Sedona Telehealth I puzzle over published research on Selank; this notebook is an editorial site, not a medical business or a source of medical advice.